Chemokine Receptors of T Cells and of B Cells in Lymphatic Filarial Infection: A Role for CCR9 in Pathogenesis
Identifieur interne : 008071 ( Main/Exploration ); précédent : 008070; suivant : 008072Chemokine Receptors of T Cells and of B Cells in Lymphatic Filarial Infection: A Role for CCR9 in Pathogenesis
Auteurs : Subash Babu ; Carla P. Blauvelt ; V. Kumaraswami [Inde] ; Thomas B. NutmanSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2005-03-15.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Brugia malayi (croissance et développement), Brugia malayi (immunologie), Brugia malayi (pathogénicité), Chimiokines (métabolisme), Femelle, Filariose lymphatique (parasitologie), Filariose lymphatique (physiopathologie), Humains, Larve (immunologie), Larve (pathogénicité), Lymphocytes B (), Lymphocytes B (métabolisme), Lymphocytes T (), Lymphocytes T (métabolisme), Lymphoedème (parasitologie), Lymphoedème (physiopathologie), Maladie chronique, Mâle, Phénotype, Récepteurs CCR, Récepteurs aux chimiokines (métabolisme), Régulation positive.
- MESH :
- croissance et développement : Brugia malayi.
- immunologie : Brugia malayi, Larve.
- métabolisme : Chimiokines, Lymphocytes B, Lymphocytes T, Récepteurs aux chimiokines.
- parasitologie : Filariose lymphatique, Lymphoedème.
- pathogénicité : Brugia malayi, Larve.
- physiopathologie : Filariose lymphatique, Lymphoedème.
- Adulte, Adulte d'âge moyen, Animaux, Femelle, Humains, Lymphocytes B, Lymphocytes T, Maladie chronique, Mâle, Phénotype, Récepteurs CCR, Régulation positive.
English descriptors
- KwdEn :
- Adult, Animals, B-Lymphocytes (classification), B-Lymphocytes (metabolism), Brugia malayi (growth & development), Brugia malayi (immunology), Brugia malayi (pathogenicity), Chemokines (metabolism), Chronic Disease, Elephantiasis, Filarial (parasitology), Elephantiasis, Filarial (physiopathology), Female, Humans, Larva (immunology), Larva (pathogenicity), Lymphedema (parasitology), Lymphedema (physiopathology), Male, Middle Aged, Phenotype, Receptors, CCR, Receptors, Chemokine (metabolism), T-Lymphocytes (classification), T-Lymphocytes (metabolism), Up-Regulation.
- MESH :
- chemical , metabolism : Chemokines, Receptors, Chemokine.
- classification : B-Lymphocytes, T-Lymphocytes.
- growth & development : Brugia malayi.
- immunology : Brugia malayi, Larva.
- metabolism : B-Lymphocytes, T-Lymphocytes.
- parasitology : Elephantiasis, Filarial, Lymphedema.
- pathogenicity : Brugia malayi, Larva.
- physiopathology : Elephantiasis, Filarial, Lymphedema.
- Adult, Animals, Chronic Disease, Female, Humans, Male, Middle Aged, Phenotype, Receptors, CCR, Up-Regulation.
Abstract
We examined the expression of chemokine receptors on the surfaces of T cells and B cells from 27 individuals either with lymphatic filarial disease (lymphedema), with the asymptomatic or subclinical form of filarial infection, or without filarial infection. Individuals with lymphedema exhibited increased percentages of CCR9-expressing T cells and CCR9-expressing B cells and decreased percentages of both CXCR1-and-CXCR3–expressing T cells and CXCR1-and-CXCR3–expressing B cells, compared with asymptomatic or uninfected individuals. A significant correlation was found between the grade of lymphedema and the percentage of CCR9-expressing T cells and CCR9-expressing B cells. The percentages of CCR9-expressing T cells and CCR9-expressing B cells from patients with lymphedema was significantly up-regulated in response to live, infective-stage larvae of Brugia malayi but not to microfilariae of this parasite. Finally, individuals with lymphedema had significantly higher concentrations of interleukin-8, macrophage inflammatory protein (MIP)–1α, MIP-1β, monocyte chemotactic protein 1, thymus-and-activation–regulated chemokine, and interferon-inducible protein 10 in their serum than did uninfected individuals. These results suggest that chemokine receptors (particularly CCR9) are involved in the pathogenesis of lymphatic filarial disease and that trafficking of particular cellular subsets may influence clinical outcome
Url:
DOI: 10.1086/427658
Affiliations:
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xml:lang="en"><term>Adult</term><term>Animals</term><term>B-Lymphocytes (classification)</term><term>B-Lymphocytes (metabolism)</term><term>Brugia malayi (growth & development)</term><term>Brugia malayi (immunology)</term><term>Brugia malayi (pathogenicity)</term><term>Chemokines (metabolism)</term><term>Chronic Disease</term><term>Elephantiasis, Filarial (parasitology)</term><term>Elephantiasis, Filarial (physiopathology)</term><term>Female</term><term>Humans</term><term>Larva (immunology)</term><term>Larva (pathogenicity)</term><term>Lymphedema (parasitology)</term><term>Lymphedema (physiopathology)</term><term>Male</term><term>Middle Aged</term><term>Phenotype</term><term>Receptors, CCR</term><term>Receptors, Chemokine (metabolism)</term><term>T-Lymphocytes (classification)</term><term>T-Lymphocytes (metabolism)</term><term>Up-Regulation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Brugia malayi (croissance et développement)</term><term>Brugia malayi (immunologie)</term><term>Brugia malayi (pathogénicité)</term><term>Chimiokines (métabolisme)</term><term>Femelle</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (physiopathologie)</term><term>Humains</term><term>Larve (immunologie)</term><term>Larve (pathogénicité)</term><term>Lymphocytes B ()</term><term>Lymphocytes B (métabolisme)</term><term>Lymphocytes T ()</term><term>Lymphocytes T (métabolisme)</term><term>Lymphoedème (parasitologie)</term><term>Lymphoedème (physiopathologie)</term><term>Maladie chronique</term><term>Mâle</term><term>Phénotype</term><term>Récepteurs CCR</term><term>Récepteurs aux chimiokines (métabolisme)</term><term>Régulation positive</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chemokines</term><term>Receptors, Chemokine</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>B-Lymphocytes</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Brugia malayi</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Brugia malayi</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia malayi</term><term>Larve</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Larva</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>B-Lymphocytes</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chimiokines</term><term>Lymphocytes B</term><term>Lymphocytes T</term><term>Récepteurs aux chimiokines</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Brugia malayi</term><term>Larva</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Brugia malayi</term><term>Larve</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Chronic Disease</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Phenotype</term><term>Receptors, CCR</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Lymphocytes B</term><term>Lymphocytes T</term><term>Maladie chronique</term><term>Mâle</term><term>Phénotype</term><term>Récepteurs CCR</term><term>Régulation positive</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">We examined the expression of chemokine receptors on the surfaces of T cells and B cells from 27 individuals either with lymphatic filarial disease (lymphedema), with the asymptomatic or subclinical form of filarial infection, or without filarial infection. Individuals with lymphedema exhibited increased percentages of CCR9-expressing T cells and CCR9-expressing B cells and decreased percentages of both CXCR1-and-CXCR3–expressing T cells and CXCR1-and-CXCR3–expressing B cells, compared with asymptomatic or uninfected individuals. A significant correlation was found between the grade of lymphedema and the percentage of CCR9-expressing T cells and CCR9-expressing B cells. The percentages of CCR9-expressing T cells and CCR9-expressing B cells from patients with lymphedema was significantly up-regulated in response to live, infective-stage larvae of Brugia malayi but not to microfilariae of this parasite. Finally, individuals with lymphedema had significantly higher concentrations of interleukin-8, macrophage inflammatory protein (MIP)–1α, MIP-1β, monocyte chemotactic protein 1, thymus-and-activation–regulated chemokine, and interferon-inducible protein 10 in their serum than did uninfected individuals. These results suggest that chemokine receptors (particularly CCR9) are involved in the pathogenesis of lymphatic filarial disease and that trafficking of particular cellular subsets may influence clinical outcome</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name><name sortKey="Blauvelt, Carla P" sort="Blauvelt, Carla P" uniqKey="Blauvelt C" first="Carla P." last="Blauvelt">Carla P. Blauvelt</name><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name></noCountry><country name="Inde"><noRegion><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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